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In 2025 a man in the United States lived for a record 271 days with a gene-edited pig kidney, the longest anyone has lived with an organ from a pig.

Massachusetts General Hospital (2025)

HealthScience

The story behind the card

Tim Andrews received the kidney at Massachusetts General Hospital in Boston in January 2025. It came from a pig bred by the company eGenesis with 69 genetic changes: some pig genes switched off, some human genes added and dormant pig viruses disabled, so that the human body would be less likely to attack the organ. It worked for 271 days, more than double the previous record for a pig kidney, before it was removed in October 2025 as its function declined; he returned to dialysis and received a human kidney in January 2026. The longest any animal organ has worked in a person is still 273 days, set by a chimpanzee kidney in 1964. With far too few human donors, pig organs are now entering small clinical trials.

Türkçe oku
ABD'de bir adam, 2025'te gen düzenlemesi yapılmış bir domuz böbreğiyle rekor sayılan 271 gün yaşadı. Bu, bir insanın domuz organıyla yaşadığı en uzun süre.
Massachusetts General Hastanesi (2025)

Tim Andrews böbreği Ocak 2025'te Boston'daki Massachusetts General Hastanesi'nde aldı. Organ, eGenesis şirketinin yetiştirdiği ve 69 genetik değişiklik yapılmış bir domuzdan geliyordu: Bazı domuz genleri kapatılmış, bazı insan genleri eklenmiş, domuzun genomunda uykuda bekleyen virüsler de etkisiz hâle getirilmişti. Amaç, insan bağışıklık sisteminin organa saldırmasını önlemekti. Böbrek 271 gün çalıştı; bu, domuz böbreğinde önceki rekorun iki katından fazla. İşlevi zayıflayınca Ekim 2025'te çıkarıldı; Andrews yeniden diyalize girdi ve Ocak 2026'da ona insan böbreği nakledildi. Hayvan organında genel rekor ise hâlâ 1964'te 273 gün çalışan bir şempanze böbreğine ait. İnsan bağışçı sayısı çok yetersiz olduğundan domuz organları artık küçük klinik denemelerde deneniyor.

Sources and further reading

Background reading: Xenotransplantation
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