Most adults in the world make little lactase, the enzyme that digests milk sugar, after childhood. In several peoples with a long history of dairy farming, genetic changes that keep the enzyme working for life spread through natural selection, a trait called lactase persistence.
In Europe the most common variant sits in a stretch of DNA that switches the lactase gene (LCT) on and off; a widely cited estimate puts its first spread at roughly 7,500 years ago. Different mutations with the same effect arose independently among cattle herders in East Africa and pastoralists in the Middle East, so evolution reached one solution several times. Scientists call this gene-culture coevolution: a cultural habit, keeping animals for milk, changed which genes helped people survive. The story is more complicated than it first looked. A 2022 study in Nature found that Europeans used milk for thousands of years while the variant stayed rare, and suggested it spread fastest in famines and epidemics, when milk could make people without it seriously ill.


