Science: quotes, facts and reflections - Page 15

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Q1577

WonderHealth

Cattle in 1930s America were bleeding to death from spoiled hay. The chemical behind it became a rat poison — and then warfarin, the blood thinner that has kept millions of people from having strokes.

A Wisconsin farmer drove through a blizzard in 1933 with a dead cow and a bucket of blood that would not clot, looking for someone who could explain it. Biochemist Karl Link traced it to mouldy sweet clover, which produces an anticoagulant. Sold first as rat poison — rats die of internal bleeding — it was later found safe in controlled human doses. President Eisenhower was given it after his heart attack in 1955, which did much for its reputation. It remains one of the most prescribed drugs in the world.

Medical historyRead card

Q1587

WonderScience

After surgery in 1953, Henry Molaison could no longer form new long-term memories. He met his doctors afresh for fifty years — and in doing so became the most important patient in the history of memory research.

An operation to control severe epilepsy removed much of his hippocampus on both sides. It stopped the seizures and stopped his memory. Crucially, he could still learn physical skills — practising a tracing task, he improved daily while insisting each time he had never done it before. That split proved memory is not one system but several, stored in different places, and it underpins nearly everything we now know about how remembering works. Only after his death was his name published; in life he was known simply as H.M.

Neuroscience historyRead card

Q1591

WonderSpace

In 1908 something detonated over Siberia with enough force to flatten roughly 2,000 square kilometres of forest. More than a century on, no impact crater has ever been found.

Around 80 million trees went down, all pointing away from a single centre. The likeliest culprit is a small asteroid or comet fragment perhaps 50–60 metres across that burst in the atmosphere before reaching the ground — which is why the trees fell but nothing dug a hole. The region was so remote that no scientific expedition arrived for nineteen years. Had it come down hours later, with Earth turned a little further, it could have struck a major city. It remains the largest impact event in recorded history.

NASARead card

Q1596

WonderScience

In 1879 a researcher working on coal tar derivatives went to dinner without washing his hands and noticed his bread tasted sweet. He traced it back to the laboratory bench and found saccharin.

Fahlberg went back and, in an act of research technique no laboratory would permit today, tasted his way along the bench until he found the compound — around 300 times sweeter than sugar. He patented it without crediting his supervisor Ira Remsen, who was quietly furious for the rest of his life. Saccharin's moment came with sugar rationing in both world wars. The same story recurs: aspartame and sucralose were also found by chemists who licked something they should not have.

Chemistry historyRead card

Q1600

WonderMind

Two brothers adopted separately at birth met at 39 and found they had both married women named Linda, divorced, remarried women named Betty, named their sons James Alan, and owned dogs called Toy.

Jim Lewis and Jim Springer became the founding case of the Minnesota Study of Twins Reared Apart, which went on to follow more than a hundred separated pairs and found striking similarities in personality, taste and even mannerisms. The caution is real: some of the coincidences are less astonishing than they sound, since both were given the common name James by different families, and researchers who go looking for matches will find some. What survived scrutiny is the broader finding — that heredity shapes personality far more than mid-century psychology assumed.

Minnesota Study of Twins Reared ApartRead card

Q1602

WonderHealth

In 1854 a Soho cholera outbreak killed hundreds in ten days. John Snow mapped every death, saw them cluster around a single water pump, and persuaded the parish to remove its handle. The outbreak stopped.

Nobody yet accepted that water carried disease; the consensus blamed bad air. Snow's map of Broad Street, with a black bar for each death, is the founding document of epidemiology and one of the most influential graphics ever drawn. He also spotted the exceptions that proved him right — the local brewery workers, who drank beer, were untouched. The authorities put the pump handle back once the panic passed. Snow died four years later, before his idea was generally accepted.

London MuseumRead card

Q1605

WonderHistory

The New York Sun ran six articles claiming a great telescope had revealed the Moon's inhabitants: bison, unicorns, and winged humanoids the reporter called man-bats. Circulation soared. None of it was true.

The series was attributed to the real and respected astronomer John Herschel, then observing from South Africa and quite unaware. Written by reporter Richard Adams Locke, probably as satire on extravagant scientific claims, it was read as fact and made the Sun one of the best-selling papers in New York. There was no dramatic retraction; the paper simply moved on. Herschel was reportedly amused at first and tired of the questions later. It remains the template for every viral fabrication since.

HistoryRead card

Q1607

WonderScience

In 1912 an English gravel pit produced 'Piltdown Man' — the missing link between apes and humans. It took until 1953 to establish it was a medieval human skull joined to an orangutan jaw, filed down and stained.

It was believed partly because it flattered: it placed the earliest Englishman in Sussex and matched the assumption that a big brain evolved before an upright jaw — which is the wrong way round. Genuine African fossils were dismissed for decades because they did not fit Piltdown. Fluorine dating finally exposed it. The forger has never been identified with certainty, with suspects including the solicitor Charles Dawson who found it. It is science's most useful embarrassment: proof that the method eventually catches its own errors, if slowly.

Natural History MuseumRead card

Q1617

WonderNature

Old Tjikko looks like an ordinary small spruce on a Swedish mountainside. Its root system has been dated to around 9,550 years old — it has been regrowing its own trunk since the end of the last ice age.

The visible tree is only a few hundred years old; the organism beneath it is not. Norway spruce can clone itself by layering, where a branch touching the ground takes root and becomes a new trunk from the same genetic individual. Radiocarbon dating of the root material gave the extraordinary age. It survived the ice age as a low shrub and only grew upright as the climate warmed — a living thing that has been quietly present through the whole of human civilisation.

Umeå UniversityRead card

Q1622

WonderHealth

In the early 1990s a Welsh trial tested a new compound for angina. It did little for chest pain, but the men in the study were oddly reluctant to hand back the leftover tablets. The drug was renamed Viagra.

Sildenafil was designed to relax blood vessels and improve blood flow to the heart. It underperformed on that measure at Pfizer's trial site in Merthyr Tydfil, and the study was heading for closure when nurses reported the persistent side effect volunteers were declining to discuss in detail. The company changed direction, and it was approved in 1998. The same molecule is also used, under a different name, to treat pulmonary hypertension in babies — the use it was closest to being designed for all along.

Pharmaceutical historyRead card

Q1626

WonderScience

Edward Cope and Othniel Marsh spent thirty years trying to destroy one another — bribing crews, stealing fossils, dynamiting their own sites so the other could not dig them. Between them they named around 130 new dinosaurs.

The feud filled American museums and gave the world Triceratops, Stegosaurus, Diplodocus and Allosaurus. It also produced spectacular sloppiness: Marsh built an Apatosaurus with the wrong skull, an error that stood in museums for decades, and Cope once assembled a plesiosaur with its head on the tail. Both men ruined their finances and reputations, and both died with far less than they started with. Palaeontology got its golden age out of two men who could not stand each other.

History of scienceRead card

Q1627

WonderNature

In 1945 a Colorado farmer beheaded a cockerel for dinner and the bird got up and walked away. Mike the Headless Chicken lived another 18 months, fed by pipette, and toured the country.

The axe missed most of the brainstem, which controls breathing and heart rate, and a clot sealed the artery so he did not bleed out. One ear and much of the stem stayed attached, so basic functions carried on. Lloyd Olsen fed him milk and water through an eyedropper and took him on tour, where thousands queued to see him. He died in a motel when Olsen could not find the feeding equipment in time. The town of Fruita still holds a Mike the Headless Chicken festival each spring.

University of UtahRead card

Q1629

WonderSpace

Before John Glenn orbited Earth in 1962, he did not trust the electronic computer's numbers. He asked for Katherine Johnson to work the trajectory by hand — and said if she agreed the figures were right, he was ready to go.

Johnson was one of NASA's 'human computers', a Black mathematician working in a segregated division at Langley. She calculated trajectories for Alan Shepard's flight, Glenn's orbit and later Apollo 11, and helped work out the return path that brought Apollo 13's crew home. She kept working at NASA until 1986, received the Presidential Medal of Freedom in 2015, and became widely known only late in life, after the book and film Hidden Figures.

NASARead card

Q1648

StillnessMind

Forgetting why you came into a room is not age or distraction. Passing through a doorway signals to the brain that one episode has ended, and it quietly files away what you were holding.

Experiments by Gabriel Radvansky and colleagues had people carry objects between rooms, and again across the same distance within one room. Recall dropped only when a doorway was crossed — including in virtual environments, and even when participants walked back to where they started. Memory appears to be organised in event chunks, and a boundary such as a door tells the mind the previous chunk is complete. Later work suggests the effect is smaller in very familiar rooms, but the mechanism holds: your memory is keeping the current scene, not a continuous tape.

Psychology researchRead card

Q1649

DriveMind

Reviewing something four times in one evening is far weaker than reviewing it four times across a month. The forgetting between sessions is not wasted — the effort of retrieval is what builds the memory.

Hermann Ebbinghaus identified it on himself in the 1880s, and it has since become one of the most reliably replicated findings in psychology. Cramming produces a feeling of fluency that predicts exam performance badly; spaced practice feels harder and works better, because each retrieval after partial forgetting strengthens the trace. The practical version is simple — review something a day later, then a few days later, then a fortnight later. Spaced-repetition software is built entirely on this, and medical schools and language learning have adopted it wholesale.

Cognitive psychologyRead card

Q1654

DriveHealth

Working muscle releases signalling molecules into the blood that reach the brain, liver, bone and immune system. Muscle is not just for moving — it is a gland you operate by using it.

The Danish physiologist Bente Klarlund Pedersen named these molecules myokines in 2003, and hundreds have since been identified. They help explain why exercise affects so much beyond fitness — mood, blood sugar handling, bone density, inflammation, and the brain's capacity to form new connections. It reframes what training is for: not primarily an appearance or a weight number, but the regular activation of a signalling organ that otherwise stays quiet. The dose required is far lower than most people assume.

Exercise physiologyRead card

Q1655

StillnessHealth

Every waking hour, adenosine accumulates in the brain and builds the pressure to sleep. Caffeine does not remove it — it blocks the receptors. The adenosine is still there, and arrives all at once when the caffeine clears.

Adenosine is a by-product of the brain using energy, so the longer you are awake the more of it collects, and the heavier sleep feels. Caffeine is shaped enough like adenosine to sit in its receptors without activating them, which mutes the signal while the molecule keeps accumulating behind it. That is the afternoon crash: the block wears off and the full backlog registers at once. Caffeine's half-life is around five hours, so a late-afternoon coffee still has a quarter of its dose working at midnight.

Sleep scienceRead card

Q1658

DriveHealth

Adults lose roughly 3–8% of muscle mass per decade from their thirties, and faster after sixty. The loss is not inevitable at that rate — resistance training and adequate protein slow it sharply, at any age.

Sarcopenia is age-related loss of muscle mass and strength, and it matters far beyond appearance: muscle underpins balance, blood sugar regulation, bone loading and the ability to get up unaided. Trials in people in their eighties and nineties, including nursing-home residents, have produced substantial strength gains within weeks of starting supervised resistance work. Protein needs rise rather than fall with age, because older muscle responds less readily to the same amount. It is one of the few declines with a genuinely well-evidenced countermeasure.

Geriatric medicineRead card

Q1660

WonderHealth

Bone is not inert scaffolding. Cells are constantly dissolving old bone and laying down new, so the skeleton you have now is largely not the one you had a decade ago.

Osteoclasts break down bone tissue and osteoblasts rebuild it, in a continuous cycle that repairs micro-damage and releases calcium when the body needs it. The process responds directly to load: bone laid under strain gets stronger, which is why weight-bearing exercise builds density and why astronauts lose it rapidly in weightlessness. The balance tips with age, with breakdown outpacing rebuilding, and that shift is what osteoporosis is. The turnover rate varies by bone type, but the whole skeleton is substantially replaced over roughly a decade.

Human biologyRead card

Q1662

DriveScience

Katalin Karikó spent decades being told her work on mRNA was a dead end. She was demoted repeatedly and pushed off the tenure track. That work became the foundation of the mRNA covid vaccines, and won a Nobel Prize.

mRNA is the molecule that carries instructions from DNA to the cell's protein factories. Karikó's idea was to write your own instructions and have the body build the medicine itself — but injected mRNA triggered a violent immune response, and grant after grant was refused. At the University of Pennsylvania she was demoted four times. Working with Drew Weissman, she found in 2005 that swapping one building block let mRNA slip past the immune system. Fifteen years later that fix was in billions of arms, and in 2023 the two of them shared the Nobel Prize in Medicine.

Nobel PrizeRead card

Q1663

DriveTechnology

John Goodenough co-created the rechargeable battery that runs phones, laptops and electric cars. He received the Nobel Prize in 2019 at the age of 97 — the oldest person ever to be given one — and kept going into the lab afterwards.

He did not begin studying physics until after serving in the Second World War, and was told he was starting too late. He was 57 when he made the breakthrough that gave lithium batteries enough voltage to be useful. He never earned significant royalties from it. In his nineties he was still publishing, still chasing a safer solid-state battery, and reportedly said that he had no intention of retiring while he could still be useful. He died at 100.

Nobel PrizeRead card

Q1664

DriveHealth

Doctors were certain stomach ulcers came from stress and spicy food. Barry Marshall thought a bacterium caused them, could not get anyone to listen, and swallowed a dish of it to prove his point. He became ill within days.

In 1984, working in Perth with the pathologist Robin Warren, Marshall could not find an animal model and could not persuade the field. So he drank a broth of Helicobacter pylori. He developed gastritis, proved the bacterium colonised a healthy stomach, and treated himself with antibiotics. The implication was enormous: a disease affecting millions was curable with a short course of pills rather than managed for life. He and Warren received the Nobel Prize in Medicine in 2005.

Nobel PrizeRead card

Q1665

DriveScience

Alfred Wegener noticed that Africa and South America fit together like torn paper, and proposed in 1912 that the continents drift. Geologists ridiculed him. He was proved right decades after he died on the ice.

His evidence was good — matching coastlines, matching rock formations, identical fossils on shores now separated by an ocean. His weakness was that he could not explain what force could shove a continent. That gap let the field dismiss him, sometimes savagely; one geologist called it delirious ravings. Wegener died at fifty on a Greenland expedition, still unaccepted. In the 1960s, mapping of the sea floor revealed plates spreading apart, and the mechanism appeared. Plate tectonics is now the organising idea of the earth sciences.

History of scienceRead card

Q1666

DriveScience

Gregor Mendel worked out the basic laws of inheritance by breeding pea plants in a monastery garden, and published in 1866. His paper was almost entirely ignored until sixteen years after his death.

He grew and counted some 28,000 pea plants over eight years, tracking traits like flower colour and seed shape, and found they were passed on in clean mathematical ratios. The work was rigorous and quantitative, which is precisely why the naturalists of the day did not know what to do with it. He was elected abbot and administration swallowed the rest of his life. In 1900 three separate botanists rediscovered his paper independently, and modern genetics started from it.

History of scienceRead card