Viruses cannot reproduce without getting inside a living cell, yet some have left permanent traces in us. Roughly 5 to 8 per cent of human DNA comes from ancient viruses that inserted their genes into the reproductive cells of our distant ancestors.
Retroviruses, the family that includes HIV, copy their genetic material into DNA and insert it into the chromosomes of the cells they infect. Usually this happens in ordinary body cells and ends with the host. But when it happened in a cell that went on to become an egg or sperm, the viral DNA was passed to the next generation like any other gene. These relics are called endogenous retroviruses, ‘endogenous’ meaning ‘arising from within’. Over millions of years most were broken by mutations and can no longer make viruses. Some, however, were put to work. The best-known example is syncytin, a protein made from an old viral gene that once helped the virus fuse with cells. In humans it helps build the outer layer of the placenta, where cells merge into a single sheet between mother and baby.




